A simulation tool for post-GWAS genetic epidemiological studies using whole-genome or whole-exome next-gen sequencing data, with an emphasis on user-friendliness and reproducibility. Long Description (required)
Variant Simulation Tools is a module of Variant Tools for the simulation of genetic variants for sequencing-based genetic epidemiological studies. Although multiple simulation engines are provided, the core of VST is a novel forward-time simulation engine that simulates real nucleotide sequences of the human genome using DNA mutation models, fine-scale recombination maps, and a selection model based on amino acid changes of translated protein sequences. The design of VST allows users to easily create and distribute simulation methods and simulated datasets for a variety of applications and encourages fair comparison between statistical methods through the use of existing or reproduced simulated datasets. http://varianttools.sourceforge.net/Simulation/HomePage bpeng@mdanderson.org
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Summary of Proposed Changes Current Citations/Applications
[Pubmed ID: 25395236 ],
Peng B ,
Reproducible simulations of realistic samples for next-generation sequencing studies using variant simulation tools. ,
Genet Epidemiol ,
01-01-2015 ,
https://www.ncbi.nlm.nih.gov/pubmed/?term=25395236, Primary Citation