Recently certified
Basic Package Attributes
Title REvolver
Short Description Modeling sequence evolution under domain constraints
Long Description REvolver is a program to simulate protein sequence evolution. REvolver automatically integrates domain information described by a profile Hidden Markov Model (pHMM) into the simulation. In the simulation of protein evolution it often had been assumed that sites evolve identically and independently from each other. This simplification is necessary since information concerning site specific evolution is frequently unavailable. However, homologous sequences and domains have been collected, aligned, and pHMMs built. The pHMM describes the variability and shared characteristics of sequences that share a common ancestor. Here we do have knowledge about what sites are conserved, at what positions in the sequences insertions are more likely, or what sites can be deleted. Pfam (Finn et al., 2010) and SMART (Letunic, Doerks and Bork, 2009) are examples for databases providing such data. REvolver is the first method, for simulating protein sequence evolution that integrates this pre-existing information about evolution in an automatic fashion.
Last Release 7 years, 6 months ago
GSR Certification This simulator has not yet been evaluated for GSR Certification. Learn more about or request GSR Certification.
Author verificationThe basic description provided was derived from a website or publications by the GSR team and has not yet been verified by the simulation author. To modify this entry or add more information, propose changes to this simulator.
Propose changes to this simulator