PhyloSim

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Title PhyloSim
Short Description An R package for the Monte Carlo simulation of sequence evolution
Long Description PhyloSim is an extensible framework for the Monte Carlo simulation of sequence evolution, written in R, using the Gillespie algorithm to integrate the actions of many concurrent processes such as substitutions, insertions and deletions. Uniquely among sequence simulation tools, PhyloSim can simulate arbitrarily complex patterns of rate variation and multiple indel processes, and allows for the incorporation of selective constraints on indel events. User-defined complex patterns of mutation and selection can be easily integrated into simulations, allowing PhyloSim to be adapted to specific needs. Key features of PhyloSim include 1) Simulation of the evolution of a set of discrete characters with arbitrary states evolving by a continuous-time Markov process with an arbitrary rate matrix. 2) Explicit implementations of the most popular substitution models (nucleotide, amino acid and codon substitution models). 3) Simulation under the popular models of among-sites rate variation, like the gamma (+G) and invariant sites plus gamma (+I+G) models. 4) The possibility to simulate under arbitrarily complex patterns of among-sites rate variation by setting the site specific rates according to any R expression. 5) ... please refer to our documentation for details.
Version 2.0.1
Project Started 2010
Last Release 7 years, 6 months ago
Homepagehttp://www.ebi.ac.uk/goldman-srv/phylosim/
Citations Sipos B, Massingham T, Jordan GE, Goldman N, PhyloSim - Monte Carlo simulation of sequence evolution in the R statistical computing environment., BMC Bioinformatics, April 19, 2011 [Abstract, cited in PMC ]
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Last evaluatedJan. 23, 2020 (227 days ago)
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